Mito Journal Club
Fall 2022
9.6.2022 Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I | Nature
9.27.2022 Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
10.4.2022 BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis | Science
10.11.2022 Mesoscale structure–function relationships in mitochondrial transcriptional condensates | PNAS
10.25.2022 A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication
11.8.2022 Prohibitin 1 regulates mtDNA release and downstream inflammatory responses | The EMBO Journal
11.15.2022 Mechanical force induces DRP1-dependent asymmetrical mitochondrial fission for quality control
11.22.2022 Break- Thanksgiving week
12.6.2022 Break -ASCB Conference and Holidays
Spring 2023
Some paper selections TBD.
1.17.2023. Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA
1.24.2023 Protein methylation in mitochondria
1.31.2023. Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
2.7.2023 Papers and patents are becoming less disruptive over time
2.21.2023 Nuclear genetic control of mtDNA copy number and heteroplasmy in humans | medRxiv
3.7.2023 Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth
3.14.2023
3.21.2023
3.28.2023
4.4.2023
4.18.2023
4.25.2023
5.2.2023
5.9.2023
Each week a different lab member selects a paper or preprint for us all to discuss the following week, serving as host for the journal club. The host prepares a short introductory presentation of 5 slides or less, explaining why they chose the paper, and a summary of the basic background needed to understand it. Starting with Figure 1, each main figure in the paper is then explained by a different lab member, with questions and discussion as we go along. We conclude by summarizing the main strength and main weakness of the work.