Publications
Recent work
Fetterman J, Chinnery PF, McClellan R, Suomalainen A, Ojala T, Lewis SC, and SW Ballinger, on behalf of the American Heart Association. Mitochondrial Genetics in Cardiovascular Health and Disease: A Scientific Statement from the American Heart Association. Circulation, In Press.
Holt KB, Zurita C, Teryoshin L, Lewis SC, EF Koslover. Diffusive Spreading Across Dynamic Mitochondrial Network Architectures. arXiv:2506.05643. In Review. [Preprint]
Boone C, Judge S, Shami A, Danna B, Ball A, Waingankar TP, Saqub H, Divakaruni AS, Lewis SC. Saturated lipid stress attenuates mitochondrial genome synthesis in human cells. bioRxiv 2025.07.28.667051. In Revision. [Preprint]
Rose K, Herrmann E, Kakudji EV, Lizarrondo J, Yasemin Celebi A, Wilfling F, Lewis SC, JH Hurley. In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment. Proc. Natl. Acad. Sci. U.S.A. 122 (31) e2511890122, https://doi.org/10.1073/pnas. 2511890122 (2025). [Preprint] [Data]
Begeman A, Smolka JA, Shami A, Waingankar TP, Lewis SC. Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress. Science Advances, 11, eads6830 (2025). DOI:10.1126/sciadv.ads6830. [Preprint] [Data]
Kakudji EV, Lewis SC. Mitochondrial nucleoids. Current Biology. 2024 Nov 4;34(21):R1067-R1068. doi: 10.1016/j.cub.2024.09.078. PMID: 39500273.
Boone C, Lewis SC. Bridging lipid metabolism and mitochondrial genome maintenance. J Biol Chem. 2024 Jun 27:107498. DOI: 10.1016/j.jbc.2024.107498. PMID: 38944117.
Mays A, et al [52 co-authors]. Juneteenth in STEMM and the barriers to equitable science. Cell, 2023 Jun 8;186(12):2510-2517. DOI: 10.1016/j.cell.2023.05.016. Epub 2023 Jun 8.
Begeman A, Babaian A, Lewis SC. Metatranscriptomic analysis uncovers prevalent viral ORFs compatible with mitochondrial translation. mSystems. 2023 May 18:e0100222. DOI: 10.1128/ msystems.01002-22. Epub ahead of print. PMID: 37199915. [Data]
Smolka JA, Lewis SC. In Situ Analysis of Mitochondrial DNA Synthesis Using Metabolic Labeling Coupled to Fluorescence Microscopy. In: Nicholls, TJ, Uhler, JP, Falkenberg, M. (eds) Mitochondrial DNA. Methods in Molecular Biology, vol 2615 (2023). Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2922-2_8.
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Marshall A, Pack AD, Owusu SA, Hultman R, Drake D, Rutaganira FUN, Namwanje M, Evans CS, Garza-Lopez E, Lewis SC, Termini CM, AshShareef S, Hicsasmaz I, Taylor B, McReynolds MR, Shuler H, Hinton AO. Navigating racialized microaggressions in STEM. Pathogens and Disease, 2021 Jun 3;79(5):ftab027. DOI: 10.1093/femspd/ftab027.
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Hinton Jr. AO, Termini C, Spencer EC, Rutaganira F, Chery D, Roby R, Vue Z, Pack AD, Brady J, Garza-Lopez E, Marshall A, Lewis SC, Schuler H, Taylor B, McReynolds MR, Palavicino-Maggio CB. Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline. Cell, 183, 568-575 October 29, 2020. DOI: https://doi.org/10.1016/j.cell.2020.09.029
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Subramanian K, Jochem A, Le Vasseur M, Lewis SC, Paulson BR, Reddy TR, Russell JD, Coon JJ, Pagliarini DJ, and JM Nunnari. Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER-mitochondria contacts. Journal of Cell Biology, Jan 2019, jcb.201808044; DOI: 10.1083/jcb.201808044.
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IMallat A, Uchiyama LF, Lewis SC, Fredenburg RA, Terada Y, Ji N, Nunnari J, Tseng C. (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin DRP1. Biochemical and Biophysical Research Communications, Mar 27, pii: S0006-291X(18)30711-3.
Lewis SC, Uchiyama LF and J Nunnari. (2016) ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells. Science, 353(6296): aaf5549. doi: 10.1126/science.aaf5549.
Highlight: Ziviani and Scorrano (2016) Cell biology: the organelle replication connection. Nature, 538, 326–327
Highlight: Bonekamp and Larsson(2018) Snapshot: Mitochondrial Nucleoid. Cell, 172, 388-388.e1
Lewis SC, Joers P, Willcox S, Griffith JD, Jacobs HT, Hyman BC. (2015) A rolling-circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans. PLoS Genetics, 11(2): e1004985.
Joers P, Lewis SC, Fukuoh A, Parhiala M, Ellila S, Holt IJ, Jacobs HT. (2013) Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. PLoS Genetics 9(9): e1003800.
Poinar G, Lewis SC, Hagen N, Hyman BC. (2011) Systematic affinity of the sea urchin parasite, Echinomermella matsi. Nematology 13:747-753.
Hyman BC, Lewis SC, Tang S, Wu Z. (2010) Rampant gene rearrangement and haplotype hypervariation among nematode mitochondrial genomes. Genetica 139(5): 611-5.
Denver DR, Dolan P, Wilhelm LJ, Sung W, Lucas-Lledó JI, Howe DK, Lewis SC, Okamoto K, Thomas WK, Lynch M, Baer CF. (2009) A genome-wide view of Caenorhabditis elegans base-substitution mutation processes. Proceedings of the National Academy of Sciences 106 (38):16310-4.
Lewis SC, Dyal LA, Hilburn CF, Weitz S, Liau WS, Lamunyon CW, Denver DR. (2009) Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi. BMC Evolutionary Biology 9(1):15.